We combine computational and experimental investigations to understand host–microbiome interactions and evolution.
Ongoing Projects
Uncovering the genetic and metabolic basis of human-microbiome coevolution, focusing on glycosylation traits.
Exploring bacterial extracellular vesicles (BEVs) from gut microbes across global populations and IBD cohorts.
Studying how lifestyle affects horizontal gene transfer patterns in gut microbes across industrialized and traditional societies.
Investigating how IgA coating of bacteria varies globally and influences gut microbial diversity and function.
Functional consequence of the Prevotella-to-Bacteroides enterotype shift in the human gut microbiome
Exploring the metabolic and ecological consequences of enterotype shifts in bioreactor-cultured gut communities.
Understanding how gut microbes metabolize cholesterol and how this trait evolved globally.
Large-scale multi-cohort metagenomic study to explore gut microbiome variation and disease associations across populations.
Analyzing bacterial replication and growth patterns in relation to lifestyle, immunity, and disease states.
Designing defined microbial consortia as alternatives to fecal microbiota transplantation for UC patients.
Using ancient and modern microbiome data to trace how human lifestyle shifts shaped microbial communities over 5,000 years.
Investigating strain-level gut microbial dynamics in IBD patients versus healthy controls over time.
Identifying disease-specific IgA-bacteria interaction patterns using longitudinal KINDRED cohort data.
Characterizing autoimmune-linked serum antibody–antigen interactions in IBD using PhIP-Seq and machine learning across EU miGut-Health and DarkMatter-NCD cohorts.
Studying global gut microbiome diversity and function across lifestyles to understand how industrialization shapes microbial ecology and health.
Host-microbiome systems in health & disease 